Effect of zoledronic acid used in the root surface treatment of late replanted teeth: a study in rats

Brazilian Dental Journal

Graziela Garrido Mori¹  Daniela Maria De Mendonça Janjacomo¹  Daniele Clapes Nunes¹  Lithiene Ribeiro Castilho¹ 

[1] ,São Paulo State University Araçatuba Dental School Integrated Clinic AreaAraçatuba SP ,Brazil

关键词: zoledronic acid;    root resorption;    tooth replantation;   

DOI  :  10.1590/S0103-64402010000500013

来源: SciELO

【 摘 要 】

This study evaluated the use of zoledronic acid, a resorption inhibitor, as a medication for root resorption treatment of late replanted teeth. Twenty-four maxillary right central incisors of rats were avulsed and kept dry for 30 min. Then, the teeth were divided into 2 groups. In group I, root surface was treated with 2% sodium fluoride for 20 min; in group II, 10-6M zoledronic acid solution was used for 20 min. All root canals were filled with calcium hydroxide. Next, teeth were replanted in their respective sockets. After 15 and 60 days post-replantation, the animals were killed and the anatomic pieces were obtained and prepared for microscopic and morphometric analyses. The results showed that zoledronic acid was capable of limiting the occurrence of root resorption and preserving cementum resorption. Further research must be performed to confirm the use of zoledronic acid in root surface treatment of late replanted teeth.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License