Clonality analysis of giant cell lesions of the jaws

Brazilian Dental Journal

Fabrício Rezende Amaral²  Carolina Cavaliéri Gomes²  Carla Silveira Oliveira²  Paulo Eduardo Alencar De Souza¹  Ricardo Santiago Gomez² 

[1] ,Federal University of Minas Gerais Dental School Department of Oral Surgery and PathologyBelo Horizonte MG ,Brazil

关键词: clonality;    clonal nature;    giant cell lesion;    giant cell granuloma;    HUMARA;   

DOI  :  10.1590/S0103-64402010000400013

来源: SciELO

【 摘 要 】

Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions.

【 授权许可】

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