Effect of Atorvastatin in radiographic density on alveolar bone loss in wistar rats

Brazilian Dental Journal

Paula Goes²  Ana Patrícia Souza Lima²  Iracema Matos Melo²  Rodrigo Otávio Citó César Rêgo¹  Vilma Lima¹ 

[1] ,Federal University of Ceará Dental School Department of Clinical DentistryFortaleza CE ,Brazil

关键词: Atorvastatin;    periodontitis;    radiography;    bone density;    rats;   

DOI  :  10.1590/S0103-64402010000300003

来源: SciELO

【 摘 要 】

The purpose of this study was to evaluate the effect of Atorvastatin (ATV) on alveolar bone loss induced in rats. Periodontitis was induced by ligature placement around the upper second left molar in a total of 24 male Wistar rats (± 200 g). Groups of 6 animals received via oral gavage either saline or ATV (1, 3 and 9 mg/kg) during 11 days. After this time, the animals were sacrificed and their maxillae were removed, defleshed, radiographed by Digora System®, and latter stained to be photographed using a digital camera. Data were analyzed statistically by ANOVA and Bonferroni test at 5% significance level and presented as mean ± SEM. ATV (9 mg/kg) caused a significant increase on gray tone variation of over 48% (118.3 ± 12.0 gray tones) when compared to saline (79.8 ± 6.2 gray tones), indicating greater radiographic density. These data were corroborated by macroscopic findings, where ATV (9 mg/kg) reduced alveolar bone loss by over 47% (p<0.05), when compared to the group of untreated animals (saline). In summary, ATV was able to prevent alveolar bone loss seen on a ligature-induced periodontitis model.

【 授权许可】

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