Double-blind, crossover, placebo-controlled clinical trial with clobetasol propionate in desquamative gingivitis

Brazilian Dental Journal

Ana Carolina Fragoso Motta²  Carina Domaneschi²  Marilena Chinali Komesu¹  Cacilda Da Silva Souza¹  Valéria Aoki¹  Dante Antonio Migliari² 

[1] ,University of São Paulo Dental School Department of Oral DiagnosisSão Paulo SP ,Brazil

关键词: immunobullous disease;    oral mucosa;    clobetasol propionate;   

DOI  :  10.1590/S0103-64402009000300011

来源: SciELO

【 摘 要 】

The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week. Next, the patients were then instructed to discontinue the treatment for 2 weeks, and were then given container 2, used in the same way and for the same length of time as container 1. Regarding signs, 17 patients presented some improvement, while 5 experienced worsening with clobetasol propionate. With the placebo, 14 patients presented some improvement, and 8 patients presented worsening. For symptoms, there was complete improvement in 2 patients, partial improvement in 12, no response in 7, and worsening in 1 with clobetasol propionate. With the placebo, there was partial improvement in 8 patients, no response in 12 and worsening in 2. No statistically significant difference was found between clobetasol and placebo (p>0.05). Within the period designed to treat the gingival lesions of the patients, clobetasol propionate did not significantly outperform the placebo.

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