Influence of local tetracycline on the microbiota of alveolar osteitis in rats

Brazilian Dental Journal

Joseane Maria Dias Bosco²  Sérgio Ricardo De Oliveira²  Álvaro Francisco Bosco²  Christiane Marie Schweitzer¹  Elerson Gaetti Jardim Júnior¹ 

[1] ,São Paulo State University Dental School of Araçatuba Department of Surgery and Integrated ClinicAraçatuba SP ,Brazil

关键词: tetracycline;    alveolar osteitis;    dry alveolus;    microorganisms;    antimicrobials;   

DOI  :  10.1590/S0103-64402008000200006

来源: SciELO

【 摘 要 】

The aim of the present study was to evaluate the effects of local tetracycline on the occurrence of alveolar osteitis in rats, and on the microbiota associated to this infection. Forty Wistar rats were randomly assigned to 4 groups (n=10): I - the rats had the maxillary right incisor extracted and the alveolar wound did not receive any treatment; II - adrenaline and Ringer-PRAS were introduced into the alveolar wound; III - the alveolar wound was irrigated with sterile saline; and IV - the alveolar wound was irrigated with an aqueous solution of tetracycline. Microbial samples from the alveolar wounds were collected 2 days after surgery and inoculated on blood agar (with and without 8 µg/mL of tetracycline) and other selective media, and were incubated in either aerobiosis or anaerobiosis at 37ºC, for 2 to 14 days. It was verified that tetracycline reduced the occurrence of alveolar osteitis in the rats and caused significant changes in the microbiota of the surgical sites, decreasing the number of anaerobes and increasing the participation of tetracycline-resistant and multi-resistant microorganisms.

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