Effect of low-dose electron radiation on rat skin wound healing

Brazilian Dental Journal

Solange Maria De Almeida²  Adriana Dibo Da Cruz²  Rívea Inês Ferreira¹  Mário Roberto Vizioli¹  Frab Norberto Bóscolo² 

[1] ,State University of Campinas School of Dentistry of Piracicaba Department of Oral DiagnosisPiracicaba SP ,Brazil

关键词: radiation;    ionizing;    radiotherapy;    wound healing;    histology;   

DOI  :  10.1590/S0103-64402007000300006

来源: SciELO

【 摘 要 】

The aim of this study was to assess the effect of low-dose electron irradiation on morphological features of the wound healing process in rat skin. Surgical wounds were inflicted with a 2.3 x 1.4 cm template on 84 male rats that were assigned to 4 groups: IG1, immediately irradiated; IG2, irradiated 3 days after inflicting the wound; CG1 and CG2, control groups. Rats in IG1 and IG2 groups had their wounds exposed to 1 Gy of 6 MeV electron beam radiation, immediately after surgery and on the third postoperative day, respectively. Qualitative and histophotometric evaluations of tissue repair structures were carried out. Data were analyzed by ANOVA and Tukey's test (alpha = 0.05) and regression analysis. The repair process was delayed since the first sacrifice time in both irradiated groups, but in IG1, wound healing was closer to that of CG1; whereas in IG2, the delay was more pronounced. Based on the histological findings, it is possible to conclude that a low-dose of electron radiation delayed tissue repair in rat skin. The delay was longer in the skin irradiated 3 days after the beginning of tissue repair. However, the low-energy electron irradiation did not prevent wound healing.

【 授权许可】

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