Residual antibacterial activity of chlorhexidine digluconate and camphorated p-monochlorophenol in calcium hydroxide-based root canal dressings

Brazilian Dental Journal

Janir Alves Soares²  Mario Roberto Leonardo¹  Mário Tanomaru Filho¹  Léa Assed Bezerra Da Silva¹  Izabel Yoko Ito¹ 

[1] ,Federal University of Vales do Jequitinhonha e Mucuri Department of Dentistry Diamantina MG ,Brazil

关键词: apical periodontitis;    calcium hydroxide;    chlorhexidine;    intracanal medicaments;    root canal infection;   

DOI  :  10.1590/S0103-64402007000100003

来源: SciELO

【 摘 要 】

The purpose of this study was to evaluate the residual antibacterial activity of several calcium hydroxide [Ca(OH)2]-based pastes, placed in root canals of dogs' teeth with induced chronic periapical lesions. Root canals were instrumented with the ProFile rotary system and filled with 4 pastes: G1 (n=16): Ca(OH)2 paste + anesthetic solution; G2 (n=20): Calen® paste + camphorated p-monochlorophenol (CMCP); G3 (n=18): Calen®; and G4 (n=18): Ca(OH)2 paste + 2% chlorhexidine digluconate. After 21 days, the pastes were removed with size 60 K-files and placed on Petri plates with agar inoculated with Micrococcus luteus ATCC 9341. Pastes that were not placed into root canals served as control. After pre-diffusion, incubation and optimization, the inhibition zones of bacterial growth were measured and analyzed by Mann-Whitney U test at 5% significance level. All pastes showed residual antibacterial activity. The control samples had larger halos (p<0.05). The mean residual antibacterial activity halos in G1, G2, G3 and G4 were 7.6; 10.4; 17.7 and 21.4 mm, respectively. The zones of bacterial growth of G4 were significantly larger than those of G1 and G2 (p<0.05). In conclusion, regardless of the vehicle and antiseptic, all Ca(OH)2-based pastes showed different degrees of measurable residual antibacterial activity. Furthermore, unlike CMCP, chlorhexidine increased significantly the antibacterial activity of Ca(OH)2.

【 授权许可】

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