Mechanism of action of sodium hypochlorite

Brazilian Dental Journal

Carlos Estrela²  Cyntia R.a. Estrela²  Eduardo Luis Barbin¹  Júlio César E. Spanó¹  Melissa A. Marchesan¹  Jesus D. Pécora¹ 

[1] ,Federal University of Goiás Faculty of Dentistry Goiânia GO ,Brazil

关键词: sodium hypochlorite;    irrigating solution;    intracanal dressing;    hipoclorito de sódio;    soluções irrigantes;    medicação intracanal;   

DOI  :  10.1590/S0103-64402002000200007

来源: SciELO

【 摘 要 】

The choice of an irrigating solution for use in infected root canals requires previous knowledge of the microorganisms responsible for the infectious process as well as the properties of different irrigating solutions. Complex internal anatomy, host defenses and microorganism virulence are important factors in the treatment of teeth with asymptomatic apical periodontitis. Irrigating solutions must have expressive antimicrobial action and tissue dissolution capacity. Sodium hypochlorite is the most used irrigating solution in endodontics, because its mechanism of action causes biosynthetic alterations in cellular metabolism and phospholipid destruction, formation of chloramines that interfere in cellular metabolism, oxidative action with irreversible enzymatic inactivation in bacteria, and lipid and fatty acid degradation. The aim of this work is to discuss the mechanism of action of sodium hypochlorite based on its antimicrobial and physico-chemical properties.

【 授权许可】

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