Histometric study of socket healing after tooth extraction in rats treated with diclofenac

Brazilian Dental Journal

Luciana Ibara Yugoshi¹  Miguel Angel Sala¹  Luiz Guilherme Brentegani¹  Teresa Lúcia Lamano Carvalho¹ 

[1] ,University of São Paulo Faculty of Dentistry of Ribeirão Preto Department of Morphology, Stomatology and PhysiologyRibeirão Preto SP ,Brazil

关键词: diclofenac;    socket healing;    tooth extraction;    diclofenaco;    alvéolo dental;    exodontia;   

DOI  :  10.1590/S0103-64402002000200003

来源: SciELO

【 摘 要 】

The purpose of the present study was to investigate if diclofenac administration interferes with the time course of alveolar wound healing in rats. Forty-two Wistar rats were used, 21 rats received 10 mg/kg/day of diclofenac one day before and 4 days after extraction of the right maxillary incisors and 21 rats received saline. The animals were sacrificed 7, 14 and 21 days after tooth extraction. Progressive new bone formation and a decrease in the volume fraction of blood clot and connective tissue from 1 to 3 weeks after tooth extraction was quantified using the histometric point-counting method. Diclofenac treatment caused a significant delay in new bone formation in association with an impairment of blood clot remission/organization.

【 授权许可】

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