Essential Oil from Flowers of Solanum stipulaceum: Composition, Effects of γ-Radiation, and Antileukemic Activity

Journal of the Brazilian Chemical Society

Aura M. B. Osorio¹  Thiago M. Silva¹  Lucienir P. Duarte¹  Vany P. Ferraz¹  Márcio T. Pereira¹  Maria O. Mercadante-simões¹  Fernanda C. G. Evangelista¹  Adriano P. Sabino¹  Antônio F. C. Alcântara¹ 

关键词: Solanum stipulaceum;    essential oil;    β-caryophyllene;    gamma-radiation;    antileukemic activity;   

DOI  :  10.5935/0103-5053.20150209

来源: SciELO

【 摘 要 】

The composition of essential oils from flowers of Solanum stipulaceum Roem & Schult collected in May and September was studied for the first time. Effects of g-radiation on volatile constituents were investigated by gas chromatography (GC) with flame ionization detector (FID). In addition, the antileukemic activity was studied by a 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) colorimetric assay against human cell lines HL-60 and THP-1. The main constituents of the essential oil of flowers collected in May were β-caryophyllene (25.8%), γ-gurjunene (11.9%), and β-gurjunene (8.2%), whereas the essential oil of flowers collected in September was mainly composed of β-caryophyllene (26.5%), caryophyllene oxide (11.0%), and γ-gurjunene (10.0%). The main components of essential oil from flowers collected in September were not significantly affected by γ-radiation at lower doses than 10.0 kGy. No cytotoxic activity in leukemic cell lines was observed for non-irradiated samples. However, irradiated samples exhibited slightly cytotoxic activity.

【 授权许可】

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