Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy)2L(NO)](PF6)n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents

Journal of the Brazilian Chemical Society

Manuela C. L. Cândido¹  Arquimedes M. Oliveira¹  Francisco O. N. Silva¹  Alda K. M. Holanda¹  Walysson Gomes Pereira¹  Eduardo H. S. Sousa¹  Zumira A. Carneiro¹  Roberto S. Silva¹  Luiz G. F. Lopes¹ 

关键词: ruthenium nitrosyl complexes;    photochemical;    photodynamic therapy;    metallodrug;   

DOI  :  10.5935/0103-5053.20150159

来源: SciELO

【 摘 要 】

The development of NO photoreleaser compounds has important potential applications on medicine, particularly on preventing topic infections and controlling cancers. Due to these expectations, the photochemical release of nitric oxide from complexes of [Ru(bpy)2LX]n+, where L = imidazole, 1-methylimidazole, sulphite and thiourea and X = NO+ and NO2− was investigated employing spectroscopic and electrochemical techniques. The release of NO was confirmed by chronoamperometry using a NO selective electrode, while the other product, mainly [RuIIH2O], was detected by UV-Visible spectroscopy and electrochemical techniques for all complexes except for thiourea. The amount of NO released by these complexes upon irradiation was determined using a new developed method using square wave voltammetry.

【 授权许可】

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