Synthesis of 4-Arylselanylpyrazoles Through Cyclocondensation Reaction Using Glycerol as Solvent

Journal of the Brazilian Chemical Society

José E. R. Nascimento¹  Daniela H. De Oliveira¹  Paola B. Abib¹  Diego Alves¹  Gelson Perin¹  Raquel G. Jacob¹ 

关键词: green chemistry;    glycerol;    pyrazole;    heterocycle;    organoselenium compound;   

DOI  :  10.5935/0103-5053.20150127

来源: SciELO

【 摘 要 】

We describe here a simple method to synthesize 4-arylselanylpyrazoles by reaction of α-arylselanyl-1,3-diketones with arylhydrazines using glycerol as solvent at 60 °C under N2 atmosphere. This is a direct cyclocondensation reaction performed with α-arylselanyl-1,3-diketones and arylhydrazines bearing electron-withdrawing and electron-donating groups affording the corresponding 4-arylselanylpyrazoles in moderate to good yields.

【 授权许可】

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