Straightforward and Clean Ultrasound-Promoted Synthesis of 2-(4,5-Dihydro‑1H‑pyrazol-1-yl)pyrimidines

Journal of the Brazilian Chemical Society

Bruna P. Kuhn¹  Juliana L. Malavolta¹  Gleison A. Casagrande¹  Cristiano Raminelli¹  Frank H. Quina¹  Claudio M. P. Pereira¹  Alex F. C. Flores¹  Lucas Pizzuti¹ 

关键词: 2-(4;    5-dihydro-1H-pyrazol-1-yl)pyrimidines;    pyrazolylpyrimidines;    sonochemistry;    pyrimidines;    pyrazoles;   

DOI  :  10.5935/0103-5053.20150078

来源: SciELO

【 摘 要 】

A series of twelve novel 2-(pyrazol-1-yl)pyrimidine derivatives was easily obtained under ultrasonic conditions by the cyclocondensation reaction of 1-carboxamidino-pyrazoles with 4-methoxyvinyl-trifluoromethyl ketones using ethanol as an environment-friendly solvent in the presence of potassium hydroxide. Comparison of the ultrasound-promoted reaction with classical methodology shows that the former is faster and gives better yield. The products were isolated in excellent purity grades without purification by chromatography or recrystalization.

【 授权许可】

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