Green Synthesis of Chalcones and Microbiological Evaluation

Journal of the Brazilian Chemical Society

Marina Ritter¹  Rosiane M. Martins¹  Silvana A. Rosa¹  Juliana L. Malavolta¹  Rafael G. Lund¹  Alex F. C. Flores¹  Claudio M. P. Pereira¹ 

关键词: chalcones;    glycerin;    microbial evaluation;   

DOI  :  10.5935/0103-5053.20150084

来源: SciELO

【 摘 要 】

A green method was developed for the synthesis of chalcones using glycerin as solvent. Subsequently, the potential microbiology activity of these molecules was evaluated by testing them against the Gram-positive bacteria Staphylococcus aureus (S. aureus) ATCC 19095 and Enterococcus faecalis (E. faecalis) ATCC 4083, the Gram-negative bacteria Escherichia coli (E. coli) ATCC 29214 and Pseudomonas aeruginosa (P. aeruginosa) ATCC 9027, and the fungus Candida albicans (C. albicans), which includes ATCC 62342 and three clinical strains of C. albicans from human oral cavities. The results showed that some chalcones exhibited moderate inhibitory activity, the most prominent being those acting against the fluconazole-resistant strains of C. albicans.

【 授权许可】

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