Synthesis of Biphenyl Tyrosine Via Cross-Coupling Suzuki-Miyaura Reaction Using Aryltrifluoroborate Salts

Journal of the Brazilian Chemical Society

Stanley N. S. Vasconcelos¹  Cristiane S. Barbeiro¹  Amna N. Khan¹  Hélio A. Stefani¹ 

关键词: tyrosine;    boron;    aryltrifluoroborates;    cross-coupling;    Suzuki-Miyaura;   

DOI  :  10.5935/0103-5053.20150038

来源: SciELO

【 摘 要 】

We reported a fast and easy method for obtaining biarylic units from tyrosine derivatives via Suzuki-Miyaura cross-coupling using a variety of substituted and unsubstituted potassium aryl- and heteroaryltrifluoroborate salts. The scope of the methodology was also extended to the formation of bis-tyrosine linked dipeptide bonds, leading to biologically interesting compounds. Some biarylic units were obtained as free amino acids through the one step cleavage reaction in good yields.

【 授权许可】

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