Chemical Constituents from Cultures of the Fungus Marasmiellus ramealis (Bull.) Singer

Journal of the Brazilian Chemical Society

Ningning Yang¹  Qingyun Ma¹  Shengzhuo Huang¹  Haofu Dai¹  Zhikai Guo¹  Xuehua Lu¹  Yuguang Wang¹  Zhifang Yu¹  Youxing Zhao¹ 

关键词: Marasmiellus ramealis (Bull.) Singer;    eudesmane;    sesquiterpenoids;    mellein;    AChE inhibition;   

DOI  :  10.5935/0103-5053.20140206

来源: SciELO

【 摘 要 】

Chemical investigation on the cultures of the fungus Marasmiellus ramealis resulted in the first isolation of eleven compounds includingtwo new eudesmane-type sesquiterpenoids14(10→1)abeo-eudesmane-13-hydroxyl-11-ene, 14(10→1)abeo-eudesmane-11,13-diol, and the new mellein derivative (R)-(–)-5-ethoxycarbonyl mellein. The first two compounds wereevaluated for their inhibitory activity against acetylcholinesterase (AChE), andproved to be active with a percentage inhibition of 29 and 41%, respectively, at aconcentration of 100 μmol L-1.

【 授权许可】

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