Voltammetric determination of gabapentin by a carbon ceramic electrode modified with multiwalled carbon nanotubes and nickel-catechol complex

Journal of the Brazilian Chemical Society

Fahimeh Jalali¹  Zahra Hassanvand¹  Parisa S. Dorraji¹ 

[1] ,Razi University Department of Chemistry Kermanshah,Iran

关键词: carbon ceramic electrode;    gabapentin;    nickel;    catechol;    electrocatalysis;   

DOI  :  10.5935/0103-5053.20140137

来源: SciELO

【 摘 要 】

Sol-gel technique was used for the fabrication of a renewable carbon ceramic electrode (CCE) modified with nickel-catechol complex (Ni-CA). The complex was deposited on the surface of a multiwalled carbon nanotubes-CCE by potential cycling in the range of 0.0-0.8 V (vs. saturated calomel electrode, SCE). Ni-CA showed electrocatalytic activity towards the redox reaction of gabapentin. A linear relationship of anodic peak current with gabapentin concentration was observed in a range of 1.25-63.23 µmol L-1 with a limit of detection of 0.5 µmol L-1. The electrode response towards gabapentin was quite reproducible and a long-term stability of the electrode (more than 2 months) was observed. The electrode was successfully applied to the determination of gabapentin in pharmaceutical preparations.

【 授权许可】

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