期刊论文详细信息
Journal of the Brazilian Chemical Society | |
Conformational analysis of 2,2'-arylmethylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) by NMR and molecular modeling | |
Marcelle De S. Ferreira1  José D. Figueroa-villar1  | |
[1],Military Institute of Engineering Department of Chemistry Medicinal Chemistry GroupRio de Janeiro RJ ,Brazil | |
关键词: 2; 2'-arylmethylene bis(3-hydroxy-5; 5-dimethyl-2-cyclohexene-1-one); NMR; molecular modeling; intermolecular hydrogen bond; structure conformation; | |
DOI : 10.5935/0103-5053.20140065 | |
来源: SciELO | |
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【 摘 要 】
2,2'-arylmethylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-ones) with para and ortho-R groups on the benzene ring were prepared and studied by nuclear magnetic resonance (NMR) and molecular modeling to determine their conformational exchanges. Experimental and calculated results indicated conformational interconversions in these compounds by rotation of benzene ring and slow movement of dimedone rings, leading to intramolecular hydrogen bond length variation. The presence of one R group at the ortho position on the benzene ring modifies conformational exchange, leading to disappearance of one intramolecular hydrogen bond and superposition of diverse NMR signals. The correlation of σp values with chemical shifts, angles and atomic charges confirms that para-R groups electronic properties are involved in conformational exchange and chemical shift variance. These results will be used to study the interaction of these compounds with bio-molecules and their use as starting materials for design and synthesis of new bioactive agents.【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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