Quantification of pharmaceuticals and personal care product residues in surface and drinking water samples by SPE and LC-ESI-MS/MS

Journal of the Brazilian Chemical Society

Maria Angelis K. Silveira¹  Sergiane S. Caldas¹  Juliana R. Guilherme¹  Fabiane P. Costa¹  Bruno De S. Guimarães¹  Maristela B. R. Cerqueira¹  Bruno M. Soares¹  Ednei G. Primel¹ 

[1] ,Universidade Federal do Rio Grande Escola de Química e Alimentos Laboratório de Análises de Compostos Orgânicos e MetaisRio Grande RS ,Brazil

关键词: SPE;    pharmaceuticals;    personal care products;    LC-ESI-MS/MS;    matrix effect;   

DOI  :  10.5935/0103-5053.20130176

来源: SciELO

【 摘 要 】

Currently, industrialized nations have faced a new problem, the contamination of water by emerging contaminants, such as pharmaceuticals and personal care products (PPCPs). A method based on solid-phase extraction (SPE) and liquid chromatography with electrospray ionization source tandem mass spectrometry was developed and validated for the determination of nimesulide, amitriptyline, enalapril, glibenclamide, haloperidol and methylparaben in water samples. In the study of SPE, a 2v5-1 fractional factorial design was used as a tool for the selection of the most significant variables in the extraction efficiency of the analytes under study. The limits of detection and quantification ranged from 0.01 to 0.2 µg L-1 and 0.05 to 1.0 µg L-1, respectively. Good linearity was obtained by a correlation coefficient (r) > 0.99 for all compounds. Recoveries ranged from 65 and 120% with relative standard deviation (RSD) lower than 20%. The method was applied to the determination of PPCPs in samples of surface and drinking water for three months. PPCPs were detected at µg L-1 levels.

【 授权许可】

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