Plastic membrane, carbon paste and multiwalled carbon nanotube composite coated copper wire sensors for determination of oxeladin citrate using batch and flow injection techniques

Journal of the Brazilian Chemical Society

Sayed I. M. Zayed²  Yousry M. Issa¹ 

[1] ,Beni Suef University Faculty of Industrial Education Beni Suef,Egypt

关键词: oxeladin citrate;    potentiometry;    flow injection;    pharmaceutical formulation;    human urine;   

DOI  :  10.5935/0103-5053.20130069

来源: SciELO

【 摘 要 】

The fabrication and performance characteristics of three novel potentiometric sensors for the determination of oxeladin citrate are described. The proposed sensors include a PVC plastic membrane sensor, a carbon paste sensor and a multiwalled carbon nanotube (MWCNT) composite coated copper wire sensor. The sensors are based on the oxeladin-phosphotungstate ion associate as electroactive material and dibutyl phthalate as solvent mediator. The developed sensors exhibited near nernstian slopes of 58.00 ± 0.22, 55.00 ± 0.69 and 57.8 ± 0.13 mV concentration decade-1 at 25 ºC, in the concentration ranges 5.96 × 10-6 - 1.00 × 10-2, 1.96 × 10-5 - 1.00 × 10-2 and 3.98 × 10-6 - 1.00 × 10-2 mol L-1 oxeladin citrate with limits of detection of 4.14 × 10-6, 8.58 × 10-6 and 2.51 × 10-6 mol L-1 oxeladin citrate for plastic membrane, carbon paste and MWCNT composite coated copper wire sensors, respectively. The proposed sensors exhibit good selectivity for oxeladin with respect to a large number of inorganic cations, sugars, amino acids and vitamins. The developed sensors were successfully applied for the potentiometric determination of oxeladin citrate in the pharmaceutical preparation (Paxeladine® capsules) in batch and flow injection conditions. The sensors were also applied for the determination of oxeladin citrate in human urine samples by using the standard addition method.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License