Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi

Journal of the Brazilian Chemical Society

Wender A. Silva²  Carlos Kleber Z. Andrade²  Hamilton B. Napolitano²  Ivo Vencato¹  Carlito Lariucci¹  Miriam. R. C. De Castro¹  Ademir J. Camargo¹ 

[1],Universidade de Brasília Instituto de Química LaQMOSBrasília DF ,Brazil

关键词: chalcones;    biological activities;    X-ray structures;    theoretical calculations;   

DOI  :  10.1590/S0103-50532013000100018

来源: SciELO

【 摘 要 】

The present work describes the antibacterial and antifungal activities of several chalcones obtained by a straight Claisen-Schmidt aldol condensation determined by the minimal inhibitory concentration against different microorganisms (Gram-positive and Gram-negative bacteria and fungi). Solid state crystal structures of seven chalcones were determined by X-ray diffraction (XRD) analysis. Chemometric studies were carried out in order to identify a potential structure-activity relationship.

【 授权许可】

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