Chemical constituents from Chirita longgangensis var. hongyao with inhibitory activity against porcine respiratory and reproductive syndrome virus

Journal of the Brazilian Chemical Society

Yao Su²  Jun-long Bi¹  Yue-hu Wang²  Ying Tan²  Jun Yang²  Hong-xin Liu²  Wei Gu²  Ge-fen Yin¹  Chun-lin Long² 

[1] ,Chinese Academy of Sciences Kunming Institute of Botany Key Laboratory of Economic Plants and BiotechnologyKunming,P. R. China

关键词: Gesneriaceae;    Chirita longgangensis var. hongyao;    quinines;    porcine reproductive and respiratory syndrome virus;   

DOI  :  10.1590/S0103-50532012005000068

来源: SciELO

【 摘 要 】

Two new quinonoids chiritalone A and B, and a new neolignan 7'E-4,9-dihydroxy-3,3',5'-trimethoxy-8,4'-oxyneolign-7'-en-9'-al, along with known (-)-8-hydroxy-α-dunnione, digiferruginol, 2,5-dimethoxy-1,4-benzoquinone and hederagenin, were isolated from the stems of Chirita longgangensis var. hongyao. The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 ± 16.9 µmol L-1 (SI = 19.9) and 43.2 ± 7.4 µmol L-1 (SI = 13.1), respectively.

【 授权许可】

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