Journal of the Brazilian Chemical Society | |
Chemical constituents from Chirita longgangensis var. hongyao with inhibitory activity against porcine respiratory and reproductive syndrome virus | |
Yao Su2  Jun-long Bi1  Yue-hu Wang2  Ying Tan2  Jun Yang2  Hong-xin Liu2  Wei Gu2  Ge-fen Yin1  Chun-lin Long2  | |
[1] ,Chinese Academy of Sciences Kunming Institute of Botany Key Laboratory of Economic Plants and BiotechnologyKunming,P. R. China | |
关键词: Gesneriaceae; Chirita longgangensis var. hongyao; quinines; porcine reproductive and respiratory syndrome virus; | |
DOI : 10.1590/S0103-50532012005000068 | |
来源: SciELO | |
【 摘 要 】
Two new quinonoids chiritalone A and B, and a new neolignan 7'E-4,9-dihydroxy-3,3',5'-trimethoxy-8,4'-oxyneolign-7'-en-9'-al, along with known (-)-8-hydroxy-α-dunnione, digiferruginol, 2,5-dimethoxy-1,4-benzoquinone and hederagenin, were isolated from the stems of Chirita longgangensis var. hongyao. The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 ± 16.9 µmol L-1 (SI = 19.9) and 43.2 ± 7.4 µmol L-1 (SI = 13.1), respectively.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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