Biosynthesis of two dihydropyrrole-polyketides from a marine-derived Penicillium citrinum

Journal of the Brazilian Chemical Society

Stelamar Romminger²  Eli F. Pimenta²  Eduardo S. Nascimento¹  Antonio G. Ferreira¹  Roberto G. S. Berlinck² 

[1] ,Universidade de São Paulo Instituto de Química de São Carlos São Carlos SP ,Brazil

关键词: Penicillium citrinum;    marine-derived fungus;    mixed biosynthesis;    dihydropyrrole;   

DOI  :  10.1590/S0103-50532012005000046

来源: SciELO

【 摘 要 】

Feeding experiments with 13C-labeled precursors were performed in order to establish the biosynthesis of two N-acylated dihydropyrroles, (8E)-1-(2,3-dihydro-1H-pyrrol-1-yl)-2-methyldec8-ene-1,3-dione (1) and 1-(2,3-dihydro-1H-pyrrol-1-yl)-2-methyldecane-1,3-dione (2), isolated from the cultures of a marine-derived Penicillium citrinum. The biosynthesis of both, 1 and 2, involves the incorporation of acetate, methionine and ornithine.

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