Metal chloride hydrates as Lewis acid catalysts in multicomponent synthesis of 2,4,5-triarylimidazoles or 2,4,5-triaryloxazoles

Journal of the Brazilian Chemical Society

Marcelo V. Marques²  Marcelo M. Ruthner¹  Luiz A. M. Fontoura²  Dennis Russowsky¹ 

[1] ,Fundação de Ciência e Tecnologia Departamento de Engenharia de Processos Cachoeirinha RS ,Brazil

关键词: triarylimidazoles;    triaryloxazoles;    multicomponent reaction;    metal halide hydrates;    Lewis acids;    Radziszewski reaction;    benzil;    benzoin;   

DOI  :  10.1590/S0103-50532012000100024

来源: SciELO

【 摘 要 】

A series of nine metal chloride hydrates (ZnCl2.2H2O, SnCl2.2H2O, CdCl2.2H2O, MnCl2.4H2O, CoCl2.6H2O, SrCl2.6H2O, NiCl2.6H2O, CrCl3.6H2O and CeCl3.7H2O) was investigated as mild and inexpensive Lewis acid catalysts to promote the multicomponent synthesis of triarylimidazoles. Reactions starting from benzil showed the best results when SnCl2.2H2O was used, while for benzoin as the starting material, CeCl3.7H2O was more efficient. All reactions were performed in EtOH as solvent. These catalysts were also successfully employed in the synthesis of triaryloxazoles.

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