Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts

Journal of the Brazilian Chemical Society

Claudio G. L. Junior¹  Fábio P. L. Silva¹  Ramon G. De Oliveira¹  Fernanda L. Subrinho¹  Natália G. De Andrade¹  Mário L. A. A. Vasconcellos¹ 

[1] ,Universidade Federal da Paraíba Departamento de Química João Pessoa PB ,Brazil

关键词: microwave-promoted reactions;    Morita-Baylis-Hillman reaction;    thermodynamic control;    temperature effect;    antiparasitic compounds;   

DOI  :  10.1590/S0103-50532011001100028

来源: SciELO

【 摘 要 】

It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 ºC or conventional protocol at 0 ºC to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 ºC.

【 授权许可】

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