Electrochemical Behavior and Determination of Fluconazole

Journal of the Brazilian Chemical Society

Éric De S. Gil²  Diogo D. Cordeiro²  Ana E. B. Matias²  Sílvia H. P. Serrano¹ 

[1] ,Universidade Federal de Goiás Faculdade de Farmácia Goiânia GO ,Brazil

关键词: fluconazole;    electrochemical behavior;    voltammetry;    electrodic material;   

DOI  :  10.1590/S0103-50532011000400021

来源: SciELO

【 摘 要 】

The electrochemical behavior of fluconazole showed an irreversible oxidation process, with the electrochemical - chemical mechanism being highly dependent on the electrode material. Adsorption of reagent at positive applied potential was observed at Pt electrode while preferential adsorption of the oxidation products was observed at Glassy Carbon surfaces. In pH below 7.0, the anodic current process was intensively decreased. At carbon paste electrode, the fluconazole oxidation current, recorded in phosphate buffer solution (pH 8.0), changed linearly with the fluconazole concentration, Ipa = 5.7×10-5 (mA) × 0.052 [Fluconazol] (μg mL-1), in the range of 48.0 to 250.0 μg mL-1. The detection limit obtained was 6.3 μg mL-1.

【 授权许可】

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