One-pot four-component synthesis of 2-aryl-3,3-dihaloacrylonitriles using potassium hexacyanoferrate(II) as environmentally benign cyanide source

Journal of the Brazilian Chemical Society

Zhouxing Zhao¹  Zheng Li¹ 

[1] ,College of Chemistry and Chemical Engineering Key Laboratory of Polymer Materials of Gansu Province ,P. R. China

关键词: cyanation;    four-component synthesis;    potassium hexacyanoferrate(II);    cyanide source;    triphenylphosphine;    2-aryl-3;    3-dichloroacrylonitriles;    2-aryl-3;    3-dibromoacrylonitriles;   

DOI  :  10.1590/S0103-50532011000100020

来源: SciELO

【 摘 要 】

An efficient route to one-pot four-component reactions of aroyl chlorides, potassium hexacyanoferrate(II), triphenylphosphine and carbon tetrahalides to synthesize 2-aryl-3,3-dichloroacrylonitriles and 2-aryl-3,3-dibromoacrylonitriles was described. This protocol has advantages of use of non-toxic cyanide source, high yield and simple work-up procedure.

【 授权许可】

CC BY   
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