N-Functionalized organolithium compounds via tellurium/lithium exchange reaction

Journal of the Brazilian Chemical Society

Fabricio Vargas¹  Fabiano T Toledo¹  João V Comasseto¹ 

[1] ,Universidade de São Paulo Instituto de Química São Paulo SP ,Brazil

关键词: tellurium;    functionalized organolithium;    dianion intermediate;    phenethylamines;   

DOI  :  10.1590/S0103-50532010001100007

来源: SciELO

【 摘 要 】

A set of tellurium amines have been evaluated in the tellurium/lithium exchange reaction. The nitrogen-containing organolithium compounds were efficiently prepared by using N-Bz tellurium amines and a mixture of n-butyllithium and lithium naphthalenide (LiNp) for performing the exchange reaction. The corresponding dianion intermediates were trapped with a wide range of electrophiles, furnishing the corresponding products in good to excellent yields. The reaction was also employed in the synthesis of phenethylamines.

【 授权许可】

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