Diphenyl diselenide a janus-faced molecule

Journal of the Brazilian Chemical Society

Cristina W Nogueira¹  João B.t Rocha¹ 

[1] ,Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas Departamento de QuímicaSanta Maria RS ,Brazil

关键词: selenium;    toxicity;    pharmacology;    thiol;    diphenyl diselenide;   

DOI  :  10.1590/S0103-50532010001100006

来源: SciELO

【 摘 要 】

In this review, we summarized the potential role of synthetic organoseleno compounds as therapeutic or toxic agents, giving emphasis almost exclusively to diphenyl diselenide, the simplest of the diaryl diselenides, and some of its analogs. We presented the main molecular aspects related to the in vitro toxicity and pharmacology of diphenyl diselenide and also provided in vivo data indicating that the interaction of diphenyl diselenide with thiols can dictate either its toxicological or pharmacological property. The papers covered in this review indicate that a limited activation of the "toxic pathway", i.e., a controlled oxidation of specific high molecular weight thiol-containing molecules could contribute to the pharmacological effects of diphenyl diselenide. In conclusion, this review reinforces the necessity of developing new diorganoyl diselenides that could interact with specific molecular targets.

【 授权许可】

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