期刊论文详细信息
Journal of the Brazilian Chemical Society | |
Chiral auxiliary-mediated enantioenrichment of (±)-ibuprofen, under steglich conditions, with secondary alcohols derived from (R)-carvone | |
Marcela Amongero1  Damian Visnovezky1  Teodoro S. Kaufman1  | |
[1] ,UNR CONICET Instituto de Química Rosario | |
关键词: ibuprofen; carvone; Steglich esterification; chiral auxiliaries; chiral secondary alcohols; | |
DOI : 10.1590/S0103-50532010000600011 | |
来源: SciELO | |
【 摘 要 】
The synthesis of a series of chiral secondary alcohols derived from (R)-carvone, and the stereochemical outcome of their reaction with (±)-ibuprofen, is reported. The racemic drug was transformed into the corresponding diastereomeric esters mediated by DCC/DMAP, affording up to 5.7:1 diastereomeric ratios of the esters derived from either (S)- or (R)-ibuprofen, depending on the type of chiral auxiliary employed.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
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RO202005130106208ZK.pdf | 387KB | download |