Sulfadiazine determination in pharmaceuticals by electrochemical reduction on a glassy carbon electrode

Journal of the Brazilian Chemical Society

Otoniel C. Braga¹  Iolana Campestrini¹  Iolanda C. Vieira¹  Almir Spinelli¹ 

[1] ,Universidade Federal de Santa Catarina Departamento de Química Florianópolis SC ,Brazil

关键词: sulfadiazine;    pharmaceuticals;    electrochemical reduction;    square-wave voltammetry;    glassy carbon electrode;   

DOI  :  10.1590/S0103-50532010000500008

来源: SciELO

【 摘 要 】

Sulfadiazine was quantified in two samples of pharmaceutical preparations by square-wave voltammetry. The analytical signal response was obtained by electrochemical reduction instead of oxidation of the sulfa drug at a glassy carbon electrode. The determination was carried out in 0.04 mol L-1 Britton-Robinson pH 6.8 buffer solution. Sulfadiazine reduction was observed at -1.49 V vs. Ag/AgCl in one well-resolved irreversible peak. The analytical curve was obtained in the concentration range of 62.7 to 340 µmol L-1 (r = 0.9986) with a detection limit of 10.9 µmol L-1. For one sample analyzed, recovery values were in the range of 94.9 to 101.1%, while for the other sample they were within 96.0 to 104.6%, indicating no matrix interference effects on the analytical results for both sulfadiazine samples. The accuracy of the electroanalytical method was compared to the standard amperometric titration method.

【 授权许可】

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