Metal complexes versus organocatalysts in asymmetric 1,3-dipolar cycloadditions

Journal of the Brazilian Chemical Society

Carmen Nájera¹  José M. Sansano¹  Miguel Yus¹ 

[1] ,Universidad de Alicante Facultad de Ciencias Instituto de Síntesis OrgánicaAlicante,Spain

关键词: asymmetric catalysis;    cycloadditions;    Lewis acids;    organocatalysts;   

DOI  :  10.1590/S0103-50532010000300002

来源: SciELO

【 摘 要 】

In this review, a comparison between the Lewis acid catalysed and organocatalysed 1,3-dipolar cycloaddition is presented with special focus on the enantioselective synthesis of five-membered hetero- or carbocyclic systems, is described. These reactions exhibit very interesting features, but the most important one is the generation of up to four stereogenic centres in only one reaction step.

【 授权许可】

CC BY   
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