Adhesion of L929 mouse ribroblast cells on poly(styrene)/poly(methyl methacrylate) films

Journal of the Brazilian Chemical Society

Adriana De Melo¹  Ângela Cristina Bet²  Jamil Assreuy²  Nito Angelo Debacher¹  Valdir Soldi¹ 

[1] ,Universidade Federal de Santa Catarina Departamento de Farmacologia Florianópolis SC ,Brazil

关键词: poly(styrene);    poly(methyl metacrylate);    block copolymer;    cell adhesion;    cytotoxicity;   

DOI  :  10.1590/S0103-50532009000900026

来源: SciELO

【 摘 要 】

Films of pure poly(styrene) (PS), pure poly(methyl methacrylate) (PMMA), a 1:1 PS/PMMA blend and a PS-b-PMMA copolymer, were prepared and tested for cell adhesion using L929 mouse fibroblasts. All polymer films were found to be good substrates for cell adhesion and proliferation, and both processes were slightly favored on films of the 1:1 PS/PMMA blend. The same results were obtained in terms of cell number and morphology for cells cultured on films, glass coverslips or plastic plates. The chemical characteristics of polymer films make them suitable supports for cell attachment and proliferation, indicating that these films are good candidates for biomedical uses.

【 授权许可】

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