An easy synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and arylamidoximes mediated by ethyl chloroformate

Journal of the Brazilian Chemical Society

Ricardo A. W. Neves Filho¹  Natércia M. M. Bezerra¹  José M. Guedes¹  Rajendra M. Srivastava¹ 

[1] ,Universidade Federal de Pernambuco Departamento de Química Fundamental Recife PE ,Brazil

关键词: carboxylic acids;    arylamidoximes;    1;    2;    4-oxadiazoles;    1H and 13C NMR spectra;   

DOI  :  10.1590/S0103-50532009000700023

来源: SciELO

【 摘 要 】

An efficient, clean and easy high-yielding synthesis of 3,5-disubstituted 1,2,4-oxadiazoles starting from mixed anhydrides (generated from carboxylic acids and ethyl chloroformate) and arylamidoximes is described.

【 授权许可】

CC BY   
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