Chemical and biological evaluation of essential oils with economic value from Lauraceae species

Journal of the Brazilian Chemical Society

Jefferson R. De A. Silva²  Dominique F. M. Do Carmo²  Érika M. Reis²  Gérzia M. C. Machado¹  Leonor L. Leon¹  Bianca O. Da Silva¹  José Luiz P. Ferreira¹  Ana Claudia F. Amaral¹ 

[1] ,Universidade Federal do Amazonas Departamento de Química Manaus AM ,Brazil

关键词: Licaria canella;    Aniba canelilla;    essential oil;    Leishmania amazonensis;    cytotoxicity;   

DOI  :  10.1590/S0103-50532009000600011

来源: SciELO

【 摘 要 】

This work compares the chemical composition of the essential oils from the leaves of Licaria canella collected in two different seasons. The results of this investigation were compared with the leaf essential oils of other species of the Lauraceae family, Aniba canelilla, collected at the same time. Both essential oils were analyzed by GC-FID and GC-MS. The results demonstrated a larger predominance of benzenoids, being the main constituent benzyl benzoate for L. canella and 1-nitro-2-phenylethane for A. canelilla. The comparison of the biological activities showed that L. canella (IC50 19 µg mL-1) was more active against Leishmania amazonensis strains and less cytotoxic in macrophage cultures than A. canelilla (IC50 40 µg mL-1). On the other hand, the L. canella oil displayed a higher cytotoxicity against Artemia salina with a lethal concentration (LC50), equal to 5.25 µg mL-1.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License