Immunomodulatory effects of palladium(II) complexes of 1,2,4-triazole on murine peritoneal macrophages

Journal of the Brazilian Chemical Society

Amadeu M. Bego²  Regina C. G. Frem²  Adelino V.g. Netto²  Antonio E. Mauro²  Sandra R. Ananias¹  Iracilda Z. Carlos¹  Michelle C. Da Rocha¹ 

[1] ,Universidade Estadual Paulista Instituto de Química de Araraquara Departamento de Química Geral e InorgânicaAraraquara SP ,Brazil

关键词: palladium(II) complexes;    1;    2;    4-triazole;    macrophages;    nitric oxide;    hydrogen peroxide;   

DOI  :  10.1590/S0103-50532009000300005

来源: SciELO

【 摘 要 】

The 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl2(µ-Htrz)}n] (1) and [{PdBr2(µ-Htrz)}n] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl2(MeCN)2] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H2O2 and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.

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