Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives

Journal of the Brazilian Chemical Society

Alcides J.m. Da Silva²  Chaquip D. Netto²  Wallace Pacienza-lima¹  Eduardo Caio Torres-santos¹  Bartira Rossi-bergmann¹  Severine Maurel¹  Alexis Valentin¹  Paulo R.r. Costa² 

[1] ,Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde Núcleo de Pesquisas de Produtos Naturais RJ ,Brazil

关键词: antineoplasic;    antiparasitic;    pterocarpans;    naphtoquinones;    oxa-Heck reaction;    antimalarial;    leishmanicide;   

DOI  :  10.1590/S0103-50532009000100026

来源: SciELO

【 摘 要 】

Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA).

【 授权许可】

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