Synthesis of hydroxy acids of dinorcholane and 5β-cholane

Journal of the Brazilian Chemical Society

L. Nahar²  A. B. Turner¹  S. D. Sarker² 

[1] ,University of Wolverhampton School of Applied Sciences Department of Pharmacy,England

关键词: 3-oxo-23;    24-dinorchol-4-en-22-al;    3-oxo-5β-cholane-24-al;    cyanohydrin silyl ether;    hydroxy acid;    NMR;   

DOI  :  10.1590/S0103-50532009000100015

来源: SciELO

【 摘 要 】

A diastereomeric mixture (55:45) of 3-oxo-23,24-dinorchol-4-en-22-hydroxy acids (4A and 4B) was synthesized from 3-oxo-23,24-dinorchol-4-en-22-al (1) in 3 steps. Similarly, 3-oxo-5β-cholane-24-hydroxy acid (9) was synthesized from 5β-cholane-3α,24-diol (5) in 4 steps. Full spectroscopic data for these compounds are presented.

【 授权许可】

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