Journal of the Brazilian Chemical Society | |
NH4Cl-CH3OH: an efficient, acid- and metal-free catalyst system for the synthesis of quinoxalines | |
Hossein Reza Darabi1  Fatemeh Tahoori1  Kioumars Aghapoor1  Fatemeh Taala1  Farshid Mohsenzadeh1  | |
[1] ,Chemistry & Chemical Engineering Research Center of IranTehran,Iran | |
关键词: quinoxalines; ammonium chloride-methanol; eco-friendly catalyst system; room temperature; | |
DOI : 10.1590/S0103-50532008000800028 | |
来源: SciELO | |
【 摘 要 】
The direct condensation of various benzene-1,2-diamines [4-R-Ph-(NH2)2, where R = H, Me, Cl and NO2] and 1,2-dicarbonyl compounds (R'-CO-CO-R', where R' = Ph, 4-MeO-Ph and Me) has been successfully achieved mostly in excellent yields (95-100%) using (NH4Cl-CH3OH) as a mild, efficient, cost-effective, readily available, acid-free, metal-free and eco-friendly catalyst system at room temperature. The procedure can be performed for a broad scope of quinoxalines, however, the nature of the functional group on the aromatic ring of 1,2-diamine exerts a strong influence on the time and the reaction yield. The condensation efficiency could be further regulated by the amount of catalyst and reaction time.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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