Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Journal of the Brazilian Chemical Society

Paulo V. Farago²  Renata P. Raffin¹  Adriana R. Pohlmann¹  Sílvia S. Guterres¹  Sônia F. Zawadzki¹ 

[1] ,Universidade Estadual de Ponta Grossa Departamento de Ciências Farmacêuticas Ponta Grossa PR ,Brazil

关键词: PHBV;    double emulsion;    hydrophilic model drug;    microparticles;   

DOI  :  10.1590/S0103-50532008000700011

来源: SciELO

【 摘 要 】

Poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) microparticles containing a water-soluble model drug, metformin hydrochloride (MH), were obtained by a double emulsion/solvent evaporation technique. Several formulations were prepared in order to investigate the influence of each composition on the encapsulation efficiency (EE). The highest value of EE (9.76%) was obtained using simultaneously pH alkalinization and NaCl addition in the external water phase of the formulation. SEM study revealed a spherical morphology and a rough surface. The crystalline diffraction intensities for the MH-loaded microparticles were lower than that verified for the physical mixture. FTIR results suggested that no chemical bond between the polymer and the drug was formed. Also thermal analyses indicated a favorable interaction between MH and PHBV. In vitro drug release demonstrated the influence of the PHBV on the dissolution profile of MH.

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