Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses

Journal of the Brazilian Chemical Society

A. O. Santini¹  H. R. Pezza¹  J. E. De Oliveira¹  L. Pezza¹ 

[1] ,Universidade Estadual Paulista Instituto de Química Araraquara SP ,Brazil

关键词: flufenamate-sensitive electrode;    potentiometry;    dosage forms;    blood serum;   

DOI  :  10.1590/S0103-50532008000100023

来源: SciELO

【 摘 要 】

The characteristics, performance, and application of an electrode, namely, Pt|Hg|Hg2(FF)2|Graphite, where FF stands for flufenamate ion, are described. This electrode responds to FF with sensitivity of (-58.6 ± 1.2) mV decade-1 over the range 1.0 × 10-6 - 1.0 × 10-2 mol L-1 at pH 6.0 - 9.0 and a detection limit of 7.1 × 10-7 mol L-1. The electrode is easily constructed at a relatively low cost with fast response time (within 10-25 s) and can be used for a period of 5 months without any considerable change in its performance characteristics. The proposed electrode displayed good selectivity for flufenamate in the presence of several substances as well as in the presence of some carboxylate and inorganic anions. The electrode was successfully applied to the determination of flufenamic acid in pharmaceuticals and human serum samples.

【 授权许可】

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