Determination of losartan associated with chlorthalidone or hydrochlorothiazide in capsules by capillary zone electrophoresis

Journal of the Brazilian Chemical Society

Manoela R. Balesteros¹  Adriana F. Faria¹  Marcone A. L. De Oliveira¹ 

[1] ,Universidade Federal de Juiz de Fora Departamento de Química Juiz de Fora MG ,Brasil

关键词: losartan;    antihypertensive;    diuretics;    pharmaceutical analysis;    capillary electrophoresis;   

DOI  :  10.1590/S0103-50532007000300009

来源: SciELO

【 摘 要 】

An alternative methodology by capillary zone electrophoresis (CZE) is proposed for the determination of losartan potassium (LOS) associated with chlorthalidone (CTD) or hydrochlorothiazide (HCT) in capsules, using 50 mmol L-1 of sodium carbonate buffer with detection at 226 nm. The electrolyte system was optimized, taking into account peak profiles, resolution, run times, baseline stability and repeatability (adsorption absence). The method was successfully applied to the analysis of pharmaceutical formulations purchased in manipulation drugstores. The analytes were baseline separated in less than 5 min. The results did not present significant difference in the 95% confidence interval in relation to the label claim values. The method can be applied to analyze these compounds and could also be employed in other similar formulated products containing these drugs.

【 授权许可】

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