Bi(OTf)3 or Bi(TFA)3 catalyzed efficient, regio- and chemoselectively synthesis of beta-hydroxy thioethers from aryl disulfides in the presence of zinc powder

Journal of the Brazilian Chemical Society

Mohammad Mehdi Khodaei¹  Ahmad Reza Khosropour¹  Kazem Ghozati¹ 

[1] ,Razi University Department of Chemistry Kermanshah,Iran

关键词: beta-hydroxy thioethers;    epoxides;    disulfides;    Bi(III) compounds;    zinc;   

DOI  :  10.1590/S0103-50532005000400032

来源: SciELO

【 摘 要 】

A new convenient method has been developed for the synthesis of beta-hydroxy thioethers with aryl disulfides and zinc powder in the presence of catalytic amounts of Bi(OTf)3 and Bi(TFA)3 in acetonitrile. The present method is very simple and the conditions tolerate a variety of acid-sensitive protecting groups. On the other hand, alkyl or benzyl disulfides afforded no corresponding thioethers under similar conditions. Then the observed regio- and chemoselectivity can be considered as a noteworthy advantage of this method.

【 授权许可】

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