Synthesis of 2,4-disubstituted thiophenols and solid state structures of thiocarbamate precursors

Journal of the Brazilian Chemical Society

Aarón Flores-figueroa¹  Víctor Arista-m.¹  Daniel Talancón-sánchez¹  Ivan Castillo¹ 

[1] ,Universidad Nacional Autónoma de México Instituto de Química México D.F. ,México

关键词: thiols;    thiophenols;    thiocarbamates;    bulky thiols;    X-ray structure;   

DOI  :  10.1590/S0103-50532005000300013

来源: SciELO

【 摘 要 】

A series of thiophenols with different ortho-substituents, 2,4-dimethylthiophenol, 2-tert-butyl-4-methylthiophenol, and 2-(1-adamantyl)-4-methylthiophenol, which display varying degrees of steric hindrance on the 2-position, was prepared from the corresponding phenols. Initial deprotonation of the phenols was achieved with NaH in dimethoxyethane, followed by treatment with N,N-dimethylthiocarbamoyl chloride, to obtain the O-arylthiocarbamates. Thermolysis of the latter compounds resulted in rearrangement, which yields the desired S-arylthiocarbamates. Finally, reduction of the S-arylthiocarbamates with LiAlH4 in THF, followed by acidic workup, allowed the isolation of the thiophenols. All products were characterized by spectroscopic techniques, and in the case of some of the thiocarbamates the solid state structures were determined by single-crystal X-ray diffraction.

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