Synthesis, spectroscopy and photosensitizing properties of hydroxynitrophenylporphyrins

Journal of the Brazilian Chemical Society

Ana Paula J. Maestrin¹  Antonio Cláudio Tedesco¹  Cláudio R. Neri¹  Maria Elisa F. Gandini¹  Osvaldo A. Serra¹  Yassuko Iamamoto¹ 

[1] ,Universidade de São Paulo FFCLRP Departamento de QuímicaRibeirão Preto SP ,Brazil

关键词: porphyrins;    photodynamic therapy;    singlet oxygen;    uric acid;   

DOI  :  10.1590/S0103-50532004000500016

来源: SciELO

【 摘 要 】

The hydroxynitrophenylporphyrins, 5,10,15,20-tetrakis(2-hydroxy-5-nitrophenyl)porphyrin and 5-mono(carboxyphenyl)-10,15,20-tris(2-hydroxy-5-nitrophenyl)porphyrin described in this work were prepared through Adler's method. These compounds were characterized by ¹H NMR and light absorption and emission spectroscopy in the visible region. In order to demonstrate the involvement of ¹O2 production, the uric (UA) acid test was carried out, which considers the decrease in the absorbance of UA at 293 nm following laser light irradiation of a solution containing UA and a photosensitizer. The results obtained demonstrate that these hydroxynitrophenylporphyrins can be considered as promising photosensitizers in PDT.

【 授权许可】

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