Natural product-like combinatorial libraries

Journal of the Brazilian Chemical Society

Pedro M. Abreu¹  Paula S. Branco¹ 

[1] ,UNL FCT Centro de Química Fina e BiotecnologiaCaparica,Portugal

关键词: natural products;    combinatorial chemistry;    drug discovery;    lead compounds;   

DOI  :  10.1590/S0103-50532003000500002

来源: SciELO

【 摘 要 】

Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a challenge to combinatorial strategies for natural products synthesis and derivatization. This article surveys the application of combinatorial techniques to the design of "natural product-looking" libraries covering a wide range of structural diversities.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License