Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns

Journal of the Brazilian Chemical Society

Shingo Makino¹  Eiji Nakanishi¹  Takashi Tsuji¹ 

[1] ,Ajinomoto Co. Pharmaceutical Company Pharmaceutical Research Laboratories,Japan

关键词: solid-phase synthesis;    drug;    quinazoline;    1;    2;    3-benzotriazin-4-one;    SynPhaseTM Lantern;    diazotization;   

DOI  :  10.1590/S0103-50532003000300019

来源: SciELO

【 摘 要 】

We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors of 1,2,3-benzotriazin-4-ones, 2-aminobenzamides, were prepared from solid-supported amines and 2-nitrobenzoic acids. Various 1,2,3-benzotriazin-4-ones were obtained with high purity using SynPhaseTM Lanterns.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License