Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components

Revista Paulista de Pediatria

Márcia Teske¹  Ana Paula B. Melges¹  Fabíola Isabel S. De Souza¹  Fernando Luiz A. Fonseca¹  Roseli Oselka S. Sarni¹ 

关键词: vitamin A;    obesity;    glucose metabolism disorders;    child;    adolescent;    vitamina A;    obesidad;    trastornos del metabolismo de glucosa;    niño;    adolescente;    vitamina A;    obesidade;    transtornos do metabolismo de glucose;    criança;    adolescente;   

DOI  :  10.1590/S0103-05822014000100009

来源: SciELO

【 摘 要 】

Objective: To evaluate obese children and adolescents' retinol plasma levels and to correlate them with metabolic syndrome components.Methods: Cross-sectional study with 61 obese children and adolescents (body mass index Z score - ZBMI>+2). Pubertal development, arterial blood pressure, body weight and height for nutritional classification and waist circumference were obtained. A 15mL blood sample was collected (after a 12-hour fasting in a low luminosity room) for retinol determination (cut-off inadequate if <30µg/dL), lipid profile (HDL-c, LDL-c, and triglycerides), oral glucose tolerance test (fasting and 120 minutes) and for high sensitivity C-reactive protein. Spearman correlation and multiple linear regression were used in the statistical analysis.Results: Mean age was 10.7±2.7 years. There was a predominance of male gender 38/61 (62%) and pre-pubertal 35/61 (57%) subjects. The average plasmatic retinol was 48.5±18.6ug/dL. Retinol deficiency and severe obesity were observed in 6/61 (10%) and 36/61 (59%), respectively. Glucose level at 120 minutes was the independent and predictive variable of plasma retinol levels [β=-0.286 (95%CI -0.013 - -0.001)].Conclusions: An independent and inverse association between plasma retinol levels and glucose tolerance was observed, suggesting an important contribution of this vitamin in the morbidities associated to obesity in children and adolescents.

【 授权许可】

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