Acta Cirurgica Brasileira | |
Comparative study of collagen deposition in the colon wall of patients operated for sigmoid diverticular disease | |
Mário Pantaroto1  Gaspar De Jesus Lopes Filho1  Clovis Antonio Lopes Pinto1  Armando Antico Filho1  | |
关键词: Colon; Collagen; Diverticulitis; Colon; Sigmoid; | |
DOI : 10.1590/S0102-865020150100000010 | |
来源: SciELO | |
【 摘 要 】
PURPOSE:To investigate the deposition of collagen in the colon wall of patients with sigmoid diverticulitis.METHODS:Samples of sigmoid tissue from 15 patients (disease group), seven men and eight women aged 37-77 years who underwent surgery for the treatment of diverticulitis, were selected. For the control group, specimens from five patients, three men and two women aged 19-58 years undergoing emergency surgery for sigmoid trauma were selected. These subjects had no associated diseases. The histological study of the surgical specimens was performed by staining with hematoxylin-eosin and picrosirius and using a histochemical method for collagen quantification.RESULTS:Collagen deposition in the colon wall in terms of area (F), glandular epithelium (E) and total area was significantly higher in the disease group compared to control (p=0.003, p=0.026 and p=0.010, respectively). The collagen volume fraction (F fraction) and muscle tissue (M fraction) were also significantly higher compared to control (p=0.044 and p=0.026, respectively). The muscle (M area) and volume fraction of glandular epithelium (E fraction) did not differ significantly between the two groups, (p=0.074 and p=1.000, respectively).CONCLUSION:In this study, collagen deposition in the colon wall of the patients operated for sigmoid diverticulitis was higher compared to patients without the disease.
【 授权许可】
CC BY
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