Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue

Acta Cirurgica Brasileira

Edson Yuzur Yasojima¹  Rubens Fernando Gonçalves Ribeiro Júnior¹  Thyago Cezar Prado Pessôa¹  Lainy Carollyne Da Costa Cavalcante¹  Suzana Rodrigues Ramos¹  Eduardo Henrique Herbster Gouveia¹  Lucas Nascimento Galvão¹  Yuri Aarão Amaral Serruya¹  Mateus Malta De Moraes¹ 

关键词: Surgical Mesh;    Collagen;    Wound Healing;    Nitrofurazone;    Rats;   

DOI  :  10.1590/S0102-865020150100000006

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effects of nitrofurazone on the correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue in rats.METHODS:A defect in the abdominal wall was created and corrected with polypropylene mesh in 20 rats. They were randomly distributed into four groups: control, fibrous mesh, nitrofurazone and nitrofurazone dip in the mesh. Euthanasia was performed in 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects.RESULTS: All animals had adhesions. However, no statistically significant difference (p>0.05) when compared between groups. Similarly microscopic analysis, in which there was no statistical significance level for the evaluated parameters such as mono and polymorphonuclear lymphocytes, granuloma, fibrosis, necrosis and collagen proliferation.CONCLUSION: There was no significant effect on the abdominal wall defect repair with polypropylene mesh surrounded by fibrous tissue when dipped in nitrofurazone 2%.

【 授权许可】

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